Mild hypothermia enhances neuroprotective actions following transient focal ischemia in rats. Combination therapy of mild hypothermia plus immunosuppressant FK506.
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چکیده
منابع مشابه
Combination drug therapy and mild hypothermia after transient focal cerebral ischemia in rats.
BACKGROUND AND PURPOSE We have recently demonstrated that pretreatment with magnesium (calcium and glutamate antagonist) and tirilazad (antioxidant) in combination with intraischemic mild hypothermia (33 degrees C) (MTH) offers superior neuroprotective efficacy in a rat model of focal transient cerebral ischemia. In the present study, we investigated the time window of this treatment strategy w...
متن کاملCombination of decompressive craniectomy and mild hypothermia ameliorates infarction volume after permanent focal ischemia in rats.
BACKGROUND AND PURPOSE Both hypothermia and decompressive craniectomy (DC) have been shown to reduce ischemic injury in experimental middle cerebral artery (MCA) infarction. This study was designed to evaluate the effect of combined DC and hypothermia on infarction size and neurological outcome in a rat model of MCA occlusion (MCAO). METHODS MCAO was performed in 72 Wistar rats assigned to gr...
متن کاملMild hypothermia reduces expression of Fas/FasL and MMP-3 after cerebral ischemia-reperfusion in rats
Objective(s):To investigate the effects of local mild hypothermia on the expression of Fas, FasL and MMP-3 after cerebral ischemia-reperfusion in rats. Materials and Methods:Male Wistar rats were divided into sham-operated group (Sham), normothermia group (NT), and hypothermia group (HT). MCAO/R model was established by Longa’s method, and reperfusion was allowed after 2 hr occlusion. Mild hypo...
متن کاملCombination drug therapy and mild hypothermia: a promising treatment strategy for reversible, focal cerebral ischemia.
BACKGROUND AND PURPOSE Hypothermia has been suggested to be the most potent therapeutic approach to reduce experimental ischemic brain injury identified to date, and mild hypothermia is increasingly used for neuroprotection during neurovascular surgery. We have recently demonstrated that combined administration of tirilazad mesylate and magnesium provides for an overall enhanced neuroprotective...
متن کاملNeuroprotection in transient focal cerebral ischemia by combination drug therapy and mild hypothermia: comparison with customary therapeutic regimen.
BACKGROUND AND PURPOSE A combined therapeutic approach has been advocated repeatedly for treatment of focal cerebral ischemia. A clinical example of combined therapy is administration of nimodipine, mannitol, dexamethasone, and barbiturates during temporary occlusion of a cerebral artery in neurovascular surgery. We have recently demonstrated outstanding neuroprotective properties of a combinat...
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ژورنال
عنوان ژورنال: Nosotchu
سال: 2000
ISSN: 0912-0726,1883-1923
DOI: 10.3995/jstroke.22.423